I took PFP for several months. After a few weeks of starting, there was less joint pain in my wrists and knees, which had been pretty constant before starting PFP. While taking PFP for months, the wrist and knee pain went away completely. I even started running some again. When I ran out, I forgot to order more and went a couple months. Then I started noticing pain in my knees again. I restarted PFP four weeks ago and the knee pain is about 85% gone again, and I expect it to be fully gone again in another couple weeks or so. This stuff works.